Answer
Requiem channels for 3 seconds, which gives 4 seconds of actual time to Lay Waste. Lay waste has a base cooldown of 1 second. Lay waste also explodes after .5 seconds (though karthus can cast other abilities while it’s waiting to explode)
At a CDR of 0
With immediate reaction time, 4 lay wastes are possible, since each will have a 1 second cooldown. Immediate reaction time is not feasible, though, so let’s call it 3 Lay wastes
At a CDR of 40
Lay waste’s cooldown becomes .6 seconds. Meaning Karthus can get of 6 Lay Wastes in 3.6 seconds. This assumes, however, that there is no more than .4 seconds of total delay between Lay Waste coming off cooldown and being cast again. This is likely difficult, but theoretically possible.
Attribution
Source : Link , Question Author : Ryre , Answer Author : Dave McClelland