What quests do you need to stop at before you make an enemy of a faction for each faction?

When completing faction/main quests in Fallout 4, you can eventually get to a point where you make a permanent enemy of a particular faction by completing a particular quest for another faction. I’d like to create a saved game where I am at the point where whatever quest I do, I will make an enemy of a faction regardless. The purpose of this is in order to check out all the game endings without having to restart the entire game again.

The question is, which quests for which factions are my stopping points and are there any things I need to be aware of to get to that nexus point? I understand I can’t make an enemy of the Minutemen but I can with all the other main factions.

Answer

  • Mass Fusion (/ Spoils of War)

    Institute vs. Brotherhood of Steel

    Upon entering the relay, one should get a warning that relaying to the
    Mass Fusion building will make them a permanent enemy to the
    Brotherhood of Steel
    . Continue and the player character will be
    teleported to the Mass Fusion executive suite.

    Alternatively, by informing the Brotherhood, Spoils of War will start,
    and boarding the Vertibird that spawns on the Prydwen will make the
    Institute hostile
    .
    source

    Once this mission has started, make your (first) save (see image below)!

  • End of the Line

    Institute vs. Railroad

    The player can choose to either warn or kill Desdemona.
    source

  • Blind Betrayal

    Brotherhood of Steel vs. Railroad

    As mentioned on the page for the quest Tactical Thinking:

    If the player is not ready to close off activities with the Railroad,
    avoid turning in [Blind Betrayal] for now.
    source

  • The Battle of Bunker Hill

    Institute vs. Railroad

    Wrong dialogue choices [in the conversation the player has with Father during the mission debriefing], such as admitting it was the player
    character’s fault, can lead to being banished from the Institute.
    source


The infographic below shows how to get as many trophies/achievements in one walkthrough, and thus notes the points at which to make a save game:

Fallout 4 main questline overview in regards to the separate factions
source unknown

Attribution
Source : Link , Question Author : The Betpet , Answer Author : Joachim

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